Testosterone Replacement Therapy And Hair Loss: Everything Explained!

If you are on testosterone replacement therapy (TRT) to treat low testosterone levels, then you may be concerned about the potential for hair loss. This is a common side effect of TRT, but there are things that you can do to minimize it. This blog post will discuss managing hair falls while on TRT therapy. We will cover the causes of hair loss associated with TRT and offer some tips for preventing it.

Why Do You Need TRT Therapy?

TRT therapy is used to treat men with low testosterone levels. Testosterone is the hormone responsible for many of the physical and sexual characteristics of men. It plays a vital role in muscle mass, bone density, red blood cell production, and sex drive. Low testosterone levels can cause a number of problems, including fatigue, depression, and erectile dysfunction. TRT replaces the missing Testosterone and can help to alleviate these symptoms.

If you are experiencing any of the symptoms mentioned above, start looking for a TRT clinic near me and get diagnosed by an expert.

Causes Of Hair Loss Associated With Trt

The connection between Testosterone and hair loss is convoluted.

According to the National Institutes of Health (NIH), 50 million males and 30 million females in the United States have male pattern baldness. The growth cycle is disrupted when hair follicles shrink, causing hair loss. Hair breaks off often as new hairs are formed, becoming finer and more delicate until there is no hair left; subsequently, the follicles cease functioning owing to hormones and particular genes.

Testosterone And Subtypes:

Testicular Testosterone is found in the body in a variety of forms. “Free” Testosterone is not attached to proteins in the body. This is the type of Testosterone that is most readily able to operate inside the body.

Testicular Testosterone is connected with albumin, a blood protein. The majority of Testosterone is bound to sex hormone-binding globulin (SHBG), which makes it inactive. If your SHBG level is high, there will be more free Testosterone in your circulation.

Dihydrotestosterone is a type of Testosterone that is produced by an enzyme. DHT is approximately five times more powerful than Testosterone. DHT is mostly found in the skin, the prostate, and hair follicles of the body.

The Hormone Behind Hair Fall:

5-alpha reductase is a biological catalyst that helps to convert Testosterone into dihydrotestosterone (DHT). DHEA, which is more often found in women, can also produce DHT. DHT may be found in the skin, hair follicles, and the prostate gland. Hair loss is caused by excessive DHT as well as the sensitivity of hair follicles to DHT. Excessively high levels of 5-dihydrotestosterone (DTH) can lead to benign prostatic hypertrophy or an enlarged prostate.

There is some evidence suggesting that baldness and prostate cancer, as well as other illnesses, are linked. Men with vertex bald spots had a 23 percent higher chance of having a heart attack than those without identifiable regions of hair loss on their heads, according to Harvard Medical School. Metabolic syndrome, diabetes, and other illnesses are being looked at for a link between DHT levels and illness.

Why Does DHT Cause Hairfall?

DHT causes hair loss by shrinking the follicles. The growth phase of the hair cycle is shortened, and new hairs become thinner and finer. Finally, the follicles go dormant and no longer produce new hair.

But actually, the sensitivity of your hair follicles is what causes baldness, not the quantity of Testosterone or DHT. This sensitivity is determined by genetics. The AR gene encodes a protein that binds to receptors in the hair follicles affected by Testosterone and DHT. If your receptors are highly sensitive, you are more likely to lose your hair.

Hair loss can be caused by a variety of factors, including age, stress, and other elements. However, genes are involved, and men who have close male relatives with MPB have an increased chance of getting the disease themselves.

Is TRT The Only Reason Behind Hair fall?

Testosterone replacement therapy is not the only reason behind hair fall. If you are on TRT and facing hair loss, it’s important to consult with a doctor to rule out any other potential causes.

Although this syndrome is linked with low testosterone levels, it appears that men with hair fall have higher amounts of the enzyme that converts Testosterone to DHT than those without. Alternatively, you could possess genes that cause your hair follicles to be highly responsive to Testosterone or DHT.

Other Potential Causes Of Hair Loss Include:

  • Autoimmune Disease
    • Alopecia Areata
    • Anemia
    • Fungal Infections
    • Scalp Psoriasis
    • Seborrheic Dermatitis
    • Telogen Effluvium (Stress)

How To Manage Hair Loss When On TRT?

If you are on testosterone therapy and experiencing hair loss, there are a few things you can do to manage the problem.

  • Talk To Your Doctor:

As we mentioned, it’s important to rule out any other potential causes of hair loss. Your doctor may also be able to adjust your dosage or recommend a different treatment option.

  • Use Minoxidil:

Minoxidil is a topical solution that is available over the counter. It is thought to help by increasing blood flow and nutrients to the follicles.

  • Try Finasteride:

Finasteride is a prescription medication that blocks the production of DHT. It can take up to six months to see results from this medication.

  • Consider Platelet-Rich Plasma Therapy:

Platelet-rich plasma therapy involves taking a sample of your blood and then injecting it into your scalp. This treatment is still being studied, but some preliminary research suggests it may be effective.


As you can see, there are a few different options available for managing hair loss while on testosterone replacement therapy. Talk to your doctor to find out which option is best for you.

Hormone levels are just one factor that can influence hair loss. If you are concerned about losing your hair, talk to your doctor about other potential causes and treatment options. TRT may help to improve some symptoms associated with low testosterone levels, but it is not a cure-all for every condition. Hair loss is a complex issue with many potential causes. Consult with a doctor to determine the best course of treatment for you.

Do you have any other tips for managing hair loss while on testosterone replacement therapy? Share them in the comments below!

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